Beautiful and willful Audrey Sterling, the daughter of missionary parents, accepts a nursing position in Tahlequah under the guidance of Dr. Elijah Keaton, a university trained Cherokee doctor and a once consecrated shaman. Despite conflicting beliefs and cultures, Audrey and Elijah succumb to a fate they cannot deny. As their relationship grows and blossoms, they travel a trail of personal tragedy and immense joy while embracing the legacy of their time. Amid a rich blend of history and romance, A Trail of Twenty Winters is set within the unthinkable tragedy of the Cherokees’ forced removal from their ancestral home in southeastern United States to Indian Territory in present day Oklahoma.