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On an incredibly simplistic level you can think of depression as occurring when your cortex thinks an abstract thought and manages to convince the rest of the brain that this is as real as a physical stressor.
- Robert M. Sapolsky -
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If I had to define a major depression in a single sentence I would describe it as a geneticneurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets.
- Robert M. Sapolsky