For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
Francis Crick
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Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
- Francis Crick -
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This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
- Francis Crick -