Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
Francis Crick
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
- Francis Crick -
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
- Francis Crick -